The GABA(A)rho receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex
Por:
Rosas-Arellano A., Parodi J., Machuca-Parra A.I., Sánchez-Gutiérrez A., Inestrosa N.C., Miledi R., Martínez-Torres A.
Publicada:
1 ago 2011
Categoría:
Neuroscience (miscellaneous)
Resumen:
A bicuculline-resistant and TPMPA-sensitive GABAergic component was identified in hippocampal neurons in culture and in acute isolated brain slices. In both preparations, total GABAergic activity showed two inactivation kinetics: fast and slow. RT-PCR, in situ hybridization (ISH) and immunohistochemistry detected expression of GABA rho subunits. Immunogold and electron microscopy indicated that the receptors are mostly extrasynaptic. In addition, by RT-PCR and immunofluorescence we found GABA rho present in amygdala and visual cortex. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Filiaciones:
Rosas-Arellano A.:
Inst Neurobiol, Lab Neurobiol Mol & Celular, Dept Neurobiol Celular & Mol, Queretaro 76230, Qro, Mexico
Parodi J.:
Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celulary Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
Machuca-Parra A.I.:
Inst Neurobiol, Lab Neurobiol Mol & Celular, Dept Neurobiol Celular & Mol, Queretaro 76230, Qro, Mexico
Sánchez-Gutiérrez A.:
Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Qro, Mexico
Inestrosa N.C.:
Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celulary Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
Miledi R.:
Inst Neurobiol, Lab Neurobiol Mol & Celular, Dept Neurobiol Celular & Mol, Queretaro 76230, Qro, Mexico
Martínez-Torres A.:
Inst Neurobiol, Lab Neurobiol Mol & Celular, Dept Neurobiol Celular & Mol, Queretaro 76230, Qro, Mexico
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