Effects of rTMS on Parkinson's disease: a longitudinal fMRI study
Por:
González-García N., Armony J.L., Soto J., Trejo D., Alegría M.A., Drucker-Colín R.
Publicada:
1 jul 2011
Resumen:
Parkinson's disease is a movement disorder whose principal symptoms are tremor, rigidity, bradykinesia and postural instability. Initially, drugs like l-dopa or dopaminergic agonists are able to control these symptoms, but with the progress of the disease these drugs become less effective. Previous studies have reported that repetitive transcranial magnetic stimulation (rTMS) can improve these motor symptoms. The objective of this study was to investigate the neural mechanisms through which 25 Hz rTMS may improve motor symptoms in Parkinson's disease. In a double-blind placebo-controlled study, we evaluated the effects of 25 Hz. rTMS in 10 Parkinson's disease patients. Fifteen rTMS sessions were performed over the primary cortex on both hemispheres (one after the other) during a 12-week period. The patients were studied using functional magnetic resonance imaging during performance of a simple tapping and a complex tapping task, 1 week before the administration of the first rTMS sessio
Filiaciones:
González-García N.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Depto Neuropatol Mol, Mexico City 04510, DF, Mexico
Armony J.L.:
Douglas Institute, Dept. of Psychiatry, McGill University, Montreal, QC, Canada
Soto J.:
Hospital General de México, Mexico, Mexico
Trejo D.:
Hospital General de México, Mexico, Mexico
Alegría M.A.:
Centro Neurológico ABC Santa Fe, Mexico, D.F., Mexico
Drucker-Colín R.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Depto Neuropatol Mol, Mexico City 04510, DF, Mexico
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