An FPGA Implementation to Detect Selective Cationic Antibacterial Peptides
Por:
Gonzalez, CP, Maganda, MAN, Arias-Estrada M., del Rio G.
Publicada:
28 jun 2011
Resumen:
Exhaustive prediction of physicochemical properties of peptide sequences is used in different areas of biological research. One example is the identification of selective cationic antibacterial peptides (SCAPs), which may be used in the treatment of different diseases. Due to the discrete nature of peptide sequences, the physicochemical properties calculation is considered a high-performance computing problem. A competitive solution for this class of problems is to embed algorithms into dedicated hardware. In the present work we present the adaptation, design and implementation of an algorithm for SCAPs prediction into a Field Programmable Gate Array (FPGA) platform. Four physicochemical properties codes useful in the identification of peptide sequences with potential selective antibacterial activity were implemented into an FPGA board. The speed-up gained in a single-copy implementation was up to 108 times compared with a single Intel processor cycle for cycle. The inherent scalabilit
Filiaciones:
Gonzalez, CP:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biochem & Struct Biol, Mexico City 04510, DF, Mexico
Arias-Estrada M.:
Computer Science Department, Instituto Nacional de Astrofísica, óptica y Electrónica, Puebla, Puebla, Mexico
del Rio G.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biochem & Struct Biol, Mexico City 04510, DF, Mexico
Gold
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