Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring
Por:
Mendoza-Rodríguez C.A., García-Guzmán M., Baranda-Avila N., Morimoto S., Perrot-Applanat M., Cerbón M.
Publicada:
1 feb 2011
Categoría:
Toxicology
Resumen:
Bisphenol A(BPA) is an estrogenic agonist compound that induces changes in diverse reproductive parameters in rats. The aim of the present study was to determine the effects of BPA given in drinking water containing 10 mg/L (approximate dose 1.2 mg/kg BW/day), administered chronically to rats during pregnancy and lactation, on reproductive tract parameters of the offspring. 79.2% of the female offspring from BPA-treated mothers presented irregular estrous cycles. As compared to the control group, a significant increase in the thickness of the uterine epithelia and stroma was observed in the BPA group. Additionally, 60% of the female offspring from BPA mothers did not undergo abundant uterine epithelial apoptosis during the estrus phase of the cycle while control animals did. In addition, a down regulation of ER alpha expression was observed in epithelial cells on estrus day. The results indicate that BPA, when administered chronically in water beverages to dams, modifies the reproducti
Filiaciones:
Mendoza-Rodríguez C.A.:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
García-Guzmán M.:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Baranda-Avila N.:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Morimoto S.:
Instituto Nacional de Ciencias Médicas y de la Nutrición S.Z., Departamento de Biología de la Reproducción, México, D.F., Mexico
Perrot-Applanat M.:
INSERM, U940, Angiogenèse et Recherche Translationelle Hospital Lariboisière, 2 rue Ambroise Paré, 75475 Paris cedex, France
Cerbón M.:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
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