Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis
Por:
Reyes, JL, Espinoza-Jimenez, AF, Gonzalez, MI, Verdin, L, Terrazas, LI
Publicada:
1 ene 2011
Categoría:
Immunology
Resumen:
Helminth infections induce strong immunoregulation that can modulate subsequent pathogenic challenges. Taenia crassiceps causes a chronic infection that induces a Th2-biased response and modulates the host cellular immune response, including reduced lymphoproliferation in response to mitogens, impaired antigen presentation and the recruitment of suppressive alternatively activated macrophages (AAM Phi)). In this study, we aimed to evaluate the ability of T. crassiceps to reduce the severity of experimental autoimmune encephalomyelitis (EAE). Only 50% of T. crassiceps-infected mice displayed EAE symptoms, which were significantly less severe than uninfected mice. This effect was associated with both decreased MOG-specific splenocyte proliferation and IL-17 production and limited leukocyte infiltration into the spinal cord. Infection with T. crassiceps induced an anti-inflammatory cytokine microenvironment, including decreased TNF-alpha production and high MOG-specific production of IL-4
Filiaciones:
Reyes, JL:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biomed, Tlalnepantla 54090, Edo De Mexico, Mexico
Espinoza-Jimenez, AF:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biomed, Tlalnepantla 54090, Edo De Mexico, Mexico
Gonzalez, MI:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biomed, Tlalnepantla 54090, Edo De Mexico, Mexico
Verdin, L:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biomed, Tlalnepantla 54090, Edo De Mexico, Mexico
Terrazas, LI:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biomed, Tlalnepantla 54090, Edo De Mexico, Mexico
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