Parasiticidal effect of 16 alpha-bromoepiandrosterone (EpiBr) in amoebiasis and cysticercosis
Por:
Carrero J.C., Cervantes-Rebolledo C., Vargas-Villavicencio J.A., Hernández-Bello R., Dowding C., Frincke J., Reading C., Morales-Montor J.
Publicada:
1 ago 2010
Resumen:
The effect of the dehydroepiandrosterone analog 16 alpha-bromoepiandrosterone (EpiBr) was tested on the tapeworm Taenia crassiceps and the protist Entamoeba histolytica, both in vivo and in vitro. Administration of EpiBr prior to infection with cysticerci in mice reduced the parasite load by 50% compared with controls. EpiBr treatment induced 20% reduction on the development of amoebic liver abscesses in hamsters. In vitro treatment of T crassiceps and E. histolytica cultures with EpiBr, reduced reproduction, motility and viability in a dose- and time-dependent fashion. These results leave open the possibility of assessing the potential of this hormonal analog as a possible anti-parasite drug, including cysticercosis and amoebiasis. (c) 2010 Elsevier Masson SAS. All rights reserved.
Filiaciones:
Carrero J.C.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
Cervantes-Rebolledo C.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
Vargas-Villavicencio J.A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
Hernández-Bello R.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
Dowding C.:
Hollis-Eden Pharmaceuticals, Inc., San Diego, CA 92121, United States
Frincke J.:
Hollis-Eden Pharmaceuticals, Inc., San Diego, CA 92121, United States
Reading C.:
Hollis-Eden Pharmaceuticals, Inc., San Diego, CA 92121, United States
Morales-Montor J.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico
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