Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism
Por:
Vergara-Galicia J., Ortiz-Andrade R., Rivera-Leyva J., Castillo-España P., Villalobos-Molina R., Ibarra-Barajas M., Gallardo-Ortiz I., Estrada-Soto S.
Publicada:
1 jul 2010
Resumen:
RMELanc-induced relaxation in aortic rings precontracted with NE, 5-HT and KCl. It also reduced NE-induced transient contraction in Ca2+-free solution and inhibited contraction induced by increasing external calcium. Nevertheless, the vasorelaxant effect of RMELanc was not reduced by ODQ, 1-alprenolol, TEA, glibenclamide, and 2-AP. Oral administration of 100 mg/kg of RMELanc exhibited a significant decrease in systolic and diastolic blood pressures in SHR rats. HPLC analysis allowed us to detect the presence of 2,7-dihydroxy-3,4,9- trimethoxyphenantrene (1), which induced a significant relaxation effect. Therefore, our results suggest that RMELanc induces vasorelaxant and antihypertensive effects by blockade of Ca2+ channels. © 2009 Elsevier B.V. All rights reserved.
Filiaciones:
Vergara-Galicia J.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
Departamento de Biotecnología, Universidad Politécnica Del Estado de Morelos, Boulevard Cuauhnáhuac 566, Colonia Lomas del Texcal, C.P. 62550. Jiutepec, Morelos, Mexico
Ortiz-Andrade R.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
Facultad de Química, Universidad Autónoma de Yucatán, Calle 41 No. 421, Mérida, Yucatán, Mexico
Rivera-Leyva J.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
Castillo-España P.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
Villalobos-Molina R.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico
Ibarra-Barajas M.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico
Gallardo-Ortiz I.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico
Estrada-Soto S.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
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