Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism


Por: Vergara-Galicia J., Ortiz-Andrade R., Rivera-Leyva J., Castillo-España P., Villalobos-Molina R., Ibarra-Barajas M., Gallardo-Ortiz I., Estrada-Soto S.

Publicada: 1 jul 2010
Resumen:
RMELanc-induced relaxation in aortic rings precontracted with NE, 5-HT and KCl. It also reduced NE-induced transient contraction in Ca2+-free solution and inhibited contraction induced by increasing external calcium. Nevertheless, the vasorelaxant effect of RMELanc was not reduced by ODQ, 1-alprenolol, TEA, glibenclamide, and 2-AP. Oral administration of 100 mg/kg of RMELanc exhibited a significant decrease in systolic and diastolic blood pressures in SHR rats. HPLC analysis allowed us to detect the presence of 2,7-dihydroxy-3,4,9- trimethoxyphenantrene (1), which induced a significant relaxation effect. Therefore, our results suggest that RMELanc induces vasorelaxant and antihypertensive effects by blockade of Ca2+ channels. © 2009 Elsevier B.V. All rights reserved.

Filiaciones:
Vergara-Galicia J.:
 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico

 Departamento de Biotecnología, Universidad Politécnica Del Estado de Morelos, Boulevard Cuauhnáhuac 566, Colonia Lomas del Texcal, C.P. 62550. Jiutepec, Morelos, Mexico

Ortiz-Andrade R.:
 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico

 Facultad de Química, Universidad Autónoma de Yucatán, Calle 41 No. 421, Mérida, Yucatán, Mexico

Rivera-Leyva J.:
 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico

Castillo-España P.:
 Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico

Villalobos-Molina R.:
 Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico

Ibarra-Barajas M.:
 Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico

Gallardo-Ortiz I.:
 Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Estado Mexico, Mexico

Estrada-Soto S.:
 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, C.P. 62209. Cuernavaca, Morelos, Mexico
ISSN: 0367326X
Editorial
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, Países Bajos
Tipo de documento: Article
Volumen: 81 Número: 5
Páginas: 350-357
WOS Id: 000279306700009
ID de PubMed: 19879929