Antioxidant-Like Effects and Protective Action of Transcranial Magnetic Stimulation in Depression Caused by Olfactory Bulbectomy
Por:
Tasset I., Drucker-Colín R., Pena, J, Jimena I., Montilla P., Medina F.J., Túnez I.
Publicada:
1 ago 2010
Resumen:
We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.
Filiaciones:
Tasset I.:
Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
Drucker-Colín R.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, Mexico City 04510, DF, Mexico
Jimena I.:
Dpto. de Ciencias Morfológicas, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain
Montilla P.:
Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
Servicio de Análisis Clínicos, Hospital Universitario Reina Sofía, Córdoba, Spain
Medina F.J.:
Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
Túnez I.:
Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain
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