Evolution of Conus peptide toxins: Analysis of Conus californicus Reeve, 1844
Por:
Biggs J.S., Watkins M., Puillandre N., Ownby, JP, Lopez-Vera E., Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S., Olivera B.M.
Publicada:
1 jul 2010
Resumen:
Conus species are characterized by their hyperdiverse toxins, encoded by a few gene superfamilies. Our phylogenies of the genus, based on mitochondrial genes, confirm previous results that C. californicus is highly divergent from all other species. Genetic and biochemical analysis of their venom peptides comprise the fifteen most abundant conopeptides and over 50 mature cDNA transcripts from the venom duct. Although C. californicus venom retains many of the general properties of other Conus species, they share only half of the toxin gene superfamilies found in other Conus species. Thus, in these two lineages, approximately half of the rapidly diversifying gene superfamilies originated after an early Tertiary split. Such results demonstrate that, unlike endogenously acting gene families, these genes are likely to be significantly more restricted in their phylogenetic distribution. In concordance with the evolutionary distance of C. californicus from other species, there are aspects of prey-capture behavior and prey preferences of this species that diverges significantly from all other Conus. © 2010 Elsevier Inc. All rights reserved.
Filiaciones:
Biggs J.S.:
University of Guam Marine Laboratory, UOG Station, Mangilao, GU 96923, United States
Watkins M.:
Department of Biology, University of Utah, Salt Lake City, UT 84105, United States
Puillandre N.:
Department of Biology, University of Utah, Salt Lake City, UT 84105, United States
Lopez-Vera E.:
Univ Nacl Autonoma Mexico, Inst Ciencias Mar & Limnol, Mexico City 04510, DF, Mexico
Christensen S.:
Department of Biology, University of Utah, Salt Lake City, UT 84105, United States
Moreno K.J.:
Centro de Investigacion Cientifica Y de Educacion, Superior de Ensenada, Km 107 Carretera Tijuana-Ensenada, C.P. 22860 Ensenada, B.C., Mexico
Bernaldez J.:
Centro de Investigacion Cientifica Y de Educacion, Superior de Ensenada, Km 107 Carretera Tijuana-Ensenada, C.P. 22860 Ensenada, B.C., Mexico
Licea-Navarro A.:
Centro de Investigacion Cientifica Y de Educacion, Superior de Ensenada, Km 107 Carretera Tijuana-Ensenada, C.P. 22860 Ensenada, B.C., Mexico
Corneli P.S.:
Department of Biology, University of Utah, Salt Lake City, UT 84105, United States
Olivera B.M.:
Department of Biology, University of Utah, Salt Lake City, UT 84105, United States
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