High ghrelin and obestatin levels and low risk of developing fatty liver
Por:
Gutierrez-Grobe Y., Villalobos-Blasquez I., Sánchez-Lara K., Villa A.R., Ponciano-Rodríguez G., Ramos M.H., Chavez-Tapia N.C., Uribe M., Méndez-Sánchez N.
Publicada:
1 ene 2010
Categoría:
Hepatology
Resumen:
Aim. Obesity and insulin resistance are associated with nonalcoholic fatty liver disease (NAFLD). It was recently reported that the ratio between levels of ghrelin and obestatin is also associated with obesity and insulin resistance. We investigated the association between the ghrelin/obestatin ratio and NAFLD. Methods. This cross-sectional study included 98 subjects (51 NAFLD patients and 47 controls). Anthropometric, metabolic and biochemical variables were measured and serum concentrations of ghrelin and obestatin were determined. Logistic regression analyses (univariate and multivariate) were conducted to determine whether NAFLD was associated with ghrelin and obestatin levels and the ghrelin/obestatin ratio. Results. We studied 51 NAFLD cases and 47 controls. Men comprised 82% of cases and 61% of controls. The mean ages of the groups differed significantly. Body mass index (P < 0.001), waist circumference (P < 0.001) and WHR (P < 0.001) were significantly greater in the NAFLD grou
Filiaciones:
Gutierrez-Grobe Y.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Villalobos-Blasquez I.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Sánchez-Lara K.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Villa A.R.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Publ Hlth Invest, Mexico City 04510, DF, Mexico
Ponciano-Rodríguez G.:
Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico
Ramos M.H.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Chavez-Tapia N.C.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Uribe M.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
Méndez-Sánchez N.:
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico
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