Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases
Por:
Petersson F., Gatalica Z., Grossmann P., Montiel, MDP, Cabrero, IA, Bulimbasic S., Swatek A., Straka L., Tichy T., Hora M., Kuroda N., Legendre B., Michal M., Hes O.
Publicada:
1 abr 2010
Resumen:
Hybrid oncocytic/chromophobe tumors (HOCT) of the kidney have been described in patients with Birt-Hogg-Dub, syndrome (BHD) and in association with renal oncocytosis without BHD. HOCT in patients without evidence of BHD or renal oncocytosis is exceedingly rare, and these cases have been poorly characterized. We have identified and studied 14 cases of HOCT from previously diagnosed renal oncocytomas (398 cases) and chromophobe renal cell carcinomas (351 cases) without evidence of BHD or renal oncocytosis. Immunohistochemical, ultrastructural, and molecular genetic studies analyzing numerical chromosomal changes, loss of heterozygosity for chromosome 3p, and mutation status of VHL, c-kit, PDGFR, and folliculin (FLCN) genes were performed. HOCTs were identified in nine men and five women (age range 40-79 years). The size of tumors ranged from 2 to 11 cm. All tumors displayed a solid alveolar architecture and were composed of cells with abundant granular eosinophilic oncocytic cytoplasm wi
Filiaciones:
Petersson F.:
Department of Pathology, National University Hospital System, Singapore, Singapore
Department of Pathology, Charles University, Charles University Hospital Plzen, Alej Svobody 80, Plzen 304 60, Czech Republic
Gatalica Z.:
Department of Pathology, Creighton University, School of Medicine, Omaha, NE, United States
Grossmann P.:
Department of Pathology, Charles University, Charles University Hospital Plzen, Alej Svobody 80, Plzen 304 60, Czech Republic
Bulimbasic S.:
Department of Pathology, University Hospital Dubrava, Zagreb, Croatia
Swatek A.:
Department of Pathology, University of Kansas, Kansas City, MO, United States
Straka L.:
Department of Pathology, Regional Hospital Presov, Prešov, Slovakia
Tichy T.:
Department of Pathology, Palacky's University Hospital Olomouc, Olomouc, Czech Republic
Hora M.:
Department of Urology, Charles University, Charles University Hospital Plzen, Plzen, Czech Republic
Kuroda N.:
Department of Pathology, Red Cross Hospital Kochi, Kochi, Japan
Legendre B.:
Transgenomic, Inc., Omaha, NE, United States
Michal M.:
Department of Pathology, Charles University, Charles University Hospital Plzen, Alej Svobody 80, Plzen 304 60, Czech Republic
Hes O.:
Department of Pathology, Charles University, Charles University Hospital Plzen, Alej Svobody 80, Plzen 304 60, Czech Republic
Department of Pathology, Institute Nacional de Cancerologia, Mexico City, Mexico
Department of Pathology, Centro Medico, Mexico City, Mexico
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