Genotoxicity studies of organically grown broccoli (Brassica oleracea var. italica) and its interactions with urethane, methyl methanesulfonate and 4-nitroquinoline-1-oxide geno


Por: Heres-Pulido, ME, Duenas-Garcia, I, Castaneda-Partida, L, Santos-Cruz, LF, Vega-Contreras, V, Rebollar-Vega, R, Gomez-Luna, JC, Duran-Diaz, A

Publicada: 1 ene 2010
Resumen:
Broccoli (Brassica oleracea var. italica) has been defined as a cancer preventive food. Nevertheless, broccoli contains potentially genotoxic compounds as well. We performed the wing spot test of Drosophila melanogaster in treatments with organically grown broccoli (OGB) and co-treatments with the promutagen urethane (URE), the direct alkylating agent methyl methanesulfonate (MMS) and the carcinogen 4-nitroquinoline-1-oxide (4-NQO) in the standard (ST) and high bioactivation (HB) crosses with inducible and high levels of cytochrome P450s (CYPs), respectively. Larvae of both crosses were chronically fed with OGB or fresh market broccoli (FMB) as a non-organically grown control, added with solvents or mutagens solutions. In both crosses, the OGB added with Tween-ethanol yielded the expected reduction in the genotoxicity spontaneous rate. OGB co-treatments did not affect the URE effect, MMS showed synergy and 4-NQO damage was modulated in both crosses. In contrast. FMB controls produced d

Filiaciones:
Heres-Pulido, ME:
 Univ Nacl Autonoma Mexico, FES Iztacala, Lab Genet Toxicol, Tlalnepantla 54090, Estado Mexico, Mexico
ISSN: 02786915





FOOD AND CHEMICAL TOXICOLOGY
Editorial
Elsevier Ltd, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 48 Número: 1
Páginas: 120-128
WOS Id: 000274460400021
ID de PubMed: 19786056