Identification of Two Common Variants Contributing to Serum Apolipoprotein B Levels in Mexicans
Por:
Weissglas-Volkov D., Plaisier C.L., Huertas-Vazquez A., Cruz-Bautista I., Riano-Barros, D, Herrera-Hernandez M., Riba L., Cantor R.M., Sinsheimer J.S., Aguilar-Salinas C.A., Tusie-Luna T., Pajukanta P.
Publicada:
1 feb 2010
Categoría:
Cardiology and Cardiovascular Medicine
Resumen:
Background and Purpose-Although the Mexican population has a high predisposition to dyslipidemias and premature coronary artery disease, this population is underinvestigated for the genetic factors conferring the high susceptibility. This study attempted to determine these genetic factors. Methods and Results-First, we investigated apolipoprotein B (apoB) levels in Mexican extended families with familial combined hyperlipidemia using a two-step testing strategy. In the screening step, we screened 5721 single-nucleotide polymorphisms (SNPs) for linkage signals with apoB. In the test step, we analyzed the 130 SNPs residing in regions of suggestive linkage signals for association with apoB. We identified significant associations with two SNPs (ie, rs1424032 [P=6.07x10(-6)] and rs1349411 [P=2.72x10(-4)]) that surpassed the significance level for the number of tests performed in the test step (P < 3.84x10(-4)). Second, these SNPs were tested for replication in Mexican hyperlipidemic case-co
Filiaciones:
Weissglas-Volkov D.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Plaisier C.L.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Huertas-Vazquez A.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Cruz-Bautista I.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Mexico City, Mexico
Herrera-Hernandez M.:
Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico
Riba L.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Cantor R.M.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Sinsheimer J.S.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Aguilar-Salinas C.A.:
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Mexico City, Mexico
Tusie-Luna T.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Pajukanta P.:
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
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