Heterogenous Population Coding of a Short-Term Memory and Decision Task


Por: Jun J.K., Miller P., Hernández A., Zainos A., Lemus L., Brody C.D., Romo R.

Publicada: 20 ene 2010
Categoría: Neuroscience (miscellaneous)

Resumen:
We examined neural spike recordings from prefrontal cortex (PFC) while monkeys performed a delayed somatosensory discrimination task. In general, PFC neurons displayed great heterogeneity in response to the task. That is, although individual cells spiked reliably in response to task variables from trial-to-trial, each cell had idiosyncratic combinations of response properties. Despite the great variety in response types, some general patterns held. We used linear regression analysis on the spike data to both display the full heterogeneity of the data and classify cells into categories. We compared different categories of cells and found little difference in their ability to carry information about task variables or their correlation to behavior. This suggests a distributed neural code for the task rather than a highly modularized one. Along this line, we compared the predictions of two theoretical models to the data. We found that cell types predicted by both models were not represente

Filiaciones:
Jun J.K.:
 Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States

Miller P.:
 Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, United States

Hernández A.:
 Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico

Zainos A.:
 Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico

Lemus L.:
 Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico

Brody C.D.:
 Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States

Romo R.:
 Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
ISSN: 02706474
Editorial
Society for Neuroscience, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 30 Número: 3
Páginas: 916-929
WOS Id: 000273779200013
ID de PubMed: 20089900