Heterogenous Population Coding of a Short-Term Memory and Decision Task
Por:
Jun J.K., Miller P., Hernández A., Zainos A., Lemus L., Brody C.D., Romo R.
Publicada:
20 ene 2010
Categoría:
Neuroscience (miscellaneous)
Resumen:
We examined neural spike recordings from prefrontal cortex (PFC) while monkeys performed a delayed somatosensory discrimination task. In general, PFC neurons displayed great heterogeneity in response to the task. That is, although individual cells spiked reliably in response to task variables from trial-to-trial, each cell had idiosyncratic combinations of response properties. Despite the great variety in response types, some general patterns held. We used linear regression analysis on the spike data to both display the full heterogeneity of the data and classify cells into categories. We compared different categories of cells and found little difference in their ability to carry information about task variables or their correlation to behavior. This suggests a distributed neural code for the task rather than a highly modularized one. Along this line, we compared the predictions of two theoretical models to the data. We found that cell types predicted by both models were not represente
Filiaciones:
Jun J.K.:
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States
Miller P.:
Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, United States
Hernández A.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Zainos A.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Lemus L.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Brody C.D.:
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States
Romo R.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
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