Two novel ternary albendazole-cyclodextrin-polymer systems: Dissolution, bioavailability and efficacy against Taenia crassiceps cysts
Por:
Palomares-Alonso F., González C.R., Bernad-Bernad, MJ, Montiel, MDC, Hernández G.P., González-Hernández I., Castro-Torres N., Estrada E.P., Jung-Cook H.
Publicada:
1 ene 2010
Resumen:
The effect of two water-soluble polymers: pectin and polyvinylpyrrolidone in combination with beta-cyclodextrin, on the dissolution, bioavailability and cysticidal efficacy of albendazole was evaluated using a commercial suspension as reference product. The dissolution of the albendazole-beta-cyclodextrin-pectin formulation was slow and incomplete (44.7%). No statistical differences in C(max) and AUC were found between this formulation and the reference. Also its cysticidal efficacy (33%) was similar to the reference (38%). The albendazole-beta-cyclodextrin-polyvinylpyrrolidone formulation exhibited the highest dissolution rate (78.5%) and its bioavailability was also significantly increased (2.3-fold). In addition, the cysticidal activity of this formulation (83%) was greater than a commercial suspension. Our results suggest that the ternary system of albendazole-beta-cyclodextrin-polyvinylpyrrolidone could be a potential alternative for the treatment of systemic helmintic diseases an
Filiaciones:
Palomares-Alonso F.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
González C.R.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Bernad-Bernad, MJ:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Montiel, MDC:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Hernández G.P.:
Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía. México DF, 14269, Mexico
González-Hernández I.:
Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía. México DF, 14269, Mexico
Castro-Torres N.:
Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía. México DF, 14269, Mexico
Estrada E.P.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioterio, Mexico City 04510, DF, Mexico
Jung-Cook H.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
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