Repeated restraint stress increases IgA concentration in rat small intestine
Por:
Reyna-Garfias H., Miliar A., Jarillo-Luna A., Rivera-Aguilar V., Pacheco-Yepez J., Baeza I., Campos-Rodríguez R.
Publicada:
1 ene 2010
Resumen:
The most abundant intestinal immunoglobulin and first line of specific immunological defense against environmental antigens is secretory immunoglobulin A. To better understand the effect of repeated stress on the secretion of intestinal IgA, the effects of restraint stress on IgA concentration and mRNA expression of the gene for the alpha-chain of IgA was assessed in both the duodenum and ileum of the rats. Restraint stress induced an increase in intestinal IgA, which was blocked by an adrenalectomy, suggesting a role of catecholamines and glucocorticoids. Whereas the blocking of glucocorticoid receptors by RU-486 did not affect the increased IgA concentration, it did reduce IgA alpha-chain mRNA expression in both segments, indicating a possible mediation on the part of glucocorticoids in IgA secretion by individual cells. Treatment with corticosterone significantly increased both the IgA concentration and IgA alpha-chain mRNA expression in ileum but not in duodenum, suggesting that gl
Filiaciones:
Reyna-Garfias H.:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Escuela Nacional de Ciencias Biológicas, México, DF CP 11340, Mexico
Miliar A.:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Escuela Nacional de Ciencias Biológicas, México, DF CP 11340, Mexico
Jarillo-Luna A.:
Departamento de Morfología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Miron, Mexico, DF CP 11340, Mexico
Rivera-Aguilar V.:
Univ Nacl Autonoma Mexico, FES Iztacala, Unidad Biol Tecnol & Prototipos UBIPRO, Dept Microbiol, Mexico City 54090, DF, Mexico
Pacheco-Yepez J.:
Laboratorio de Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle Fuentes 17, Tlalpan, México, DF CP 14000, Mexico
Baeza I.:
Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Apartado Postal 4-129, Admon, 4, México, DF, Mexico
Campos-Rodríguez R.:
Departamento Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Miron, Mexico, DF CP 11340, Mexico
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