Brachytherapy versus radical hysterectomy after external beam chemoradiation: a non-randomized matched comparison in IB2-IIB cervical cancer patients
Por:
Cetina L., Garcia-Arias A., Candelaria M., Cantú D., Rivera L., Coronel J., Bazan-Perkins B., Flores V., Gonzalez A., Duenas-Gonzalez, A
Publicada:
16 feb 2009
Resumen:
Background: A current paradigm in the treatment of cervical cancer with radiation therapy is that intracavitary brachytherapy is an essential component of radical treatment. This is a matched retrospective comparison of the results of treatment in patients treated with external beam chemoradiation (EBRT-CT)and radical hysterectomy versus those treated with identical chemoradiation followed by brachytherapy. Methods: In this non-randomized comparison EBRT-CT protocol was the same in both groups of 40 patients. In the standard treated patients, EBRT-CT was followed by one or two intracavitary Cesium (low-dose rate) applications within 2 weeks of finishing external radiation to reach a point A dose of at least 85 Gy. In the surgically treated patients, radical hysterectomy with bilateral pelvic lymph node dissection and para-aortic lymph node sampling were performed within 7 weeks after EBRT-CT. Response, toxicity and survival were evaluated. Results: A total of 80 patients were analyzed.
Filiaciones:
Cetina L.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Garcia-Arias A.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Candelaria M.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Cantú D.:
Department of Gynecological Oncology, INCan, Mexico City, Mexico
Rivera L.:
Division of Radiation Oncology, INCan, Mexico City, Mexico
Coronel J.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Bazan-Perkins B.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Flores V.:
Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Gonzalez A.:
Department of Gynecological Oncology, INCan, Mexico City, Mexico
Duenas-Gonzalez, A:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unit Biomed Res Canc, Mexico City 04510, DF, Mexico
Gold
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