Effect of acute gouty arthritis on sleep patterns: A preclinical study
Por:
Guevara-López U., Ayala-Guerrero F., Covarrubias-Gómez A., López-Muñoz F.J., Torres-González R.
Publicada:
1 feb 2009
Resumen:
Background: It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. Aims: This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. Methods: Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after intra-articular drug administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. Results: Intra-articular administration of uric acid induced: (i) an increased duration of wakefulness (p = 0.014), (ii) a decrement in the duration (p = 0.001) and number of events (p = 0.027) in REM sleep, and (iii) a decrement in the total sleep time (p = 0.001). SWS did not present statistical differences between groups. Conclusions: These data suggest that a nociceptive stimulus, induced by the intra-articular administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain-sleep interaction is needed. © 2008 European Federation of Chapters of the International Association for the Study of Pain.
Filiaciones:
Guevara-López U.:
Department of Pain and Palliative Medicine, National Institute for Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico
Medical Unit of High Specialization (UMAE), Magdalena de las Salinas, Mexican Institute for Social Security, Mexico City, Mexico
Ayala-Guerrero F.:
Univ Nacl Autonoma Mexico, Sch Psychol, Sleep Clin, Mexico City 04510, DF, Mexico
Covarrubias-Gómez A.:
Department of Pain and Palliative Medicine, National Institute for Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico
López-Muñoz F.J.:
Laboratory No. 7 Pain and Analgesia, Department of Pharmacobiology, Cinvestav-Sede Sur, Mexico
Torres-González R.:
Medical Unit of High Specialization (UMAE), Magdalena de las Salinas, Mexican Institute for Social Security, Mexico City, Mexico
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