Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells
Por:
Condes-Lara, M, Rojas-Piloni, G, Martinez-Lorenzana, G, Lopez-Hidalgo, M, Rodriguez-Jimenez, J
Publicada:
9 ene 2009
Resumen:
Recent results implicate a new original mechanism involving oxytocin (OT), as a mediator via descending fibers of the paraventricular hypothalamic nucleus (PVN), in antinociception and analgesia. In rats electrical stimulation of the PVN or topical application of OT selectively inhibits A-delta and C fiber responses in superficial dorsal horn neurons, and this inhibition is reversed by a selective OT antagonist. However, little is known about the mechanisms and the spinal elements participating in this phenomenon. Here we show that topical application of bicuculline blocks the effects produced by PVN electrical stimulation or OT application. PVN electrical stimulation also activates a subpopulation of neurons in lamina II. These PVN-On cells are responsible for the amplification of local GABAergic inhibition. This result reinforces the suggestion that a supraspinal descending control of pain processing uses a specific neuronal pathway in the spinal cord in order to produce antinocicept
Filiaciones:
Condes-Lara, M:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurofisiol, Queretaro 76230, Mexico
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