Association of Diarrheagenic Escherichia coli Pathotypes with Infection and Diarrhea among Mexican Children and Association of Atypical Enteropathogenic E-coli with Acute Diarrhea
Por:
Estrada-Garcia T., Lopez-Saucedo C., Thompson-Bonilla R., Abonce M., Lopez-Hernandez D., Santos J.I., Rosado J.L., DuPont H.L., Long K.Z.
Publicada:
1 ene 2009
Categoría:
Microbiology (medical)
Resumen:
Seventy-six children <= 2 years old were prospectively followed for 1 year in a peri-urban community of Mexico City to determine asymptomatic infection and acute diarrhea associated with diarrheagenic Escherichia coli pathotypes (DEPs). By use of a pathogen-specific multiplex PCR, DEPs were sought in 795 stool samples, of which 125 (16%) were positive for DEP; of these, 4 represented shedding episodes and 4 parasite coinfections. Most single-DEP infections (85/117) were asymptomatic (P < 0.001), and of the 32 DEP diarrhea episodes, 41% were associated with atypical enteropathogenic E. coli (aEPEC), 37.5% with enterotoxigenic E. coli, 9% with typical EPEC, 9% with enteroinvasive E. coli, and 3% with Shiga toxin-producing E. coli strains. Among the 76 children, 54 had at least one stool positive for DEP, of which 23 experienced a DEP-associated diarrhea episode. In the last group of children, DEP infection was significantly associated with a diarrhea episode (relative risk [RR] = 2.5; 95
Filiaciones:
Estrada-Garcia T.:
Department of Molecular Biomedicine, CINVESTAV-IPN, México City, Mexico
Department of Molecular Biomedicine, CINVESTAV-IPN, Av. IPN No. 2508 Col. Zacatenco, Mexico City, Mexico
Lopez-Saucedo C.:
Department of Molecular Biomedicine, CINVESTAV-IPN, México City, Mexico
Thompson-Bonilla R.:
Department of Molecular Biomedicine, CINVESTAV-IPN, México City, Mexico
Department of Immunology, ENCB-IPN, Mexico City, Mexico
Abonce M.:
Department of Molecular Biomedicine, CINVESTAV-IPN, México City, Mexico
Lopez-Hernandez D.:
Department of Molecular Biomedicine, CINVESTAV-IPN, México City, Mexico
Santos J.I.:
Hospital Infantil de México Federico Gómez, México City, Mexico
Rosado J.L.:
Universidad Autónoma de Querétaro, Queretaro, Mexico
DuPont H.L.:
Houston School of Public Health, University of Texas-Houston, St. Luke's Episcopal Hospital, Houston, TX, United States
Long K.Z.:
Nutrition, Disease and Injury Control Unit, School of Population Health, University of Queensland, Herston, QLD, Australia
Bronze
|