Heptacoordinate Tin(IV) Compounds Derived from Pyridine Schiff Bases: Synthesis, Characterization, in Vitro Cytotoxicity, Anti-inflammatory and Antioxidant Activity
Por:
Gonzalez, A, Gomez, E, Cortes-Lozada, A, Hernandez, S, Ramirez-Apan, T, Nieto-Camacho, A
Publicada:
1 ene 2009
Resumen:
Tin(IV) complexes 2a-q derived from pyridine Schiff bases were prepared and characterized. Four complexes of this series were evaluated in vitro against different carcinogenic cell lines; besides their anti-inflammatory and antioxidant properties were also tested. Combination of mass spectrometry, multinuclear NMR and Xray diffraction techniques evidenced the formation of heptacoordinated monomeric species. The X-ray diffraction analysis of 2a, 2b, 2i, 2j and 2n led to establish the heptacoordination around the tin atom in solid state and also revealed that the ligand occupies the equatorial positions of the distorted pentagonal bipyramidal geometry and the two alkyl or aryl groups the axial positions. The in-vitro study for complexes 2a-d against six tumor cell lines showed varied antiproliferative activity, the IC50 for all tested complexes was lower than that of the cis-platin. Compounds 2a-d also exhibited anti-inflammatory activity where complex 2c resulted to be more active (IC50
Filiaciones:
Gonzalez, A:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Gomez, E:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Cortes-Lozada, A:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Hernandez, S:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Ramirez-Apan, T:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Nieto-Camacho, A:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
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