Association of interleukin-6 gene Polymorphisms with bone mineral density in Mexican women


Por: Magana, JJ, Gómez R., Cisneros B., Casas L., Valdés-Flores M.

Publicada: 1 ago 2008
Categoría: Medicine (miscellaneous)

Resumen:
Background. The interleukin-6 gene (IL-6) stimulates osteoclast development; therefore, it has been implicated in osteoporosis. In this study, the association of osteoporosis with three IL-6 gene markers (a CA dinucleotide repeat and two single nucleotide polymorphisms [SNPs]: G-174C and G-572C) was tested in the Mexican population. Methods. Population sample was comprised of 70 osteoporotic women, 70 non-osteoporotic women, and 500 subjects from the general population who were genotyped for the IL-6 markers. SNPs were analyzed by real-time PCR using the 5' exonuclease assay, whereas the CA dinucleotide polymorphism was evaluated by PCR and capillary electrophoresis. The allele -phenotype relationship was analyzed with the statistical method STRAT that considered population stratification and the results were adjusted with potential confounders for osteoporosis by a longitudinal multivariate model. Results. We found that the C allele of the G-174C SNP and the A3 allele of the CA polymo

Filiaciones:
Gómez R.:
 Department of Genetics, National Rehabilitation Institute, Mexico, D.F., Mexico

Cisneros B.:
 Department of Genetics and Molecular Biology, Cinvestav-IPN, Mexico, D.F., Mexico

Casas L.:
 Department of Genetics, National Rehabilitation Institute, Mexico, D.F., Mexico

Valdés-Flores M.:
 Department of Genetics, National Rehabilitation Institute, Mexico, D.F., Mexico
ISSN: 01884409
Editorial
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, México
Tipo de documento: Article
Volumen: 39 Número: 6
Páginas: 618-624
WOS Id: 000258282100011
ID de PubMed: 18662595