Perinatal inhibition of aromatization enhances the reward value of sex
Por:
Dominguez-Salazar, E, Camacho, FJ, Paredes, RG
Publicada:
1 ago 2008
Categoría:
Behavioral Neuroscience
Resumen:
Paced mating reduces the aversive properties and increases the positive characteristics of mating, inducing a reward state. Pacing is able to induce conditioned place preference (CPP), whereas nonpaced mating does not. The authors hypothesized that the aversive properties of mating are caused by androgens from adjacent males or from the mother during fetal life. To test whether aromatization of androgens induces the aversive properties of mating, female rats were treated perinatally with 1,4,6-androstatriene-3, 17-dione (ATD) to inhibit aromatization. When adults, these females were ovariectomized and hormonally primed to evaluate CPP after paced and nonpaced mating. During paced mating, control females showed higher return latencies after ejaculation, whereas ATD-treated females did not show a similar increase. In CPP tests, both paced and nonpaced mating induced a reward state in ATD-treated females, whereas only paced mating induced a reward state in control females. These results s
Filiaciones:
Dominguez-Salazar, E:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Behav & Cognit Neurobiol, Queretaro 76230, Qro, Mexico
Camacho, FJ:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Behav & Cognit Neurobiol, Queretaro 76230, Qro, Mexico
Paredes, RG:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Behav & Cognit Neurobiol, Queretaro 76230, Qro, Mexico
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