Urinary prolactin as a reliable marker for preeclampsia, its severity, and the occurrence of adverse pregnancy outcomes
Por:
Leanos-Miranda, A, Márquez-Acosta J., Cárdenas-Mondragón G.M., Chinolla-Arellano Z.L., Rivera-Leaños R., Bermejo-Huerta S., Romero-Arauz J.F., Alvarez-Jiménez G., Ramos-León J.C., Ulloa-Aguirre A.
Publicada:
1 jul 2008
Resumen:
Context: It has been proposed that preeclampsia may result from of an imbalance in angiogenic factors. Although prolactin (PRL) is mainly related to lactation, it is also involved in other biological functions, including angiogenesis. Objective: Our objective was to determine the relationship among preeclampsia, serum and urinary PRL (uPRL) levels, and excretion of antiangiogenic PRL fragments in urine. Study design: Using a cross-sectional design, uPRL and serum PRL levels, and the presence of PRL isoforms were determined in 546 pregnant women: 207 healthy pregnant, 124 with gestational hypertension, 48 with mild preeclampsia, and 167 with severe preeclampsia (sPE). Results: uPRL concentrations were significantly (P < 0.001) higher in preeclampsia (11.99 ng/mg creatinine) than in healthy pregnancy (0.20 ng/mg creatinine) and gestational hypertension (0.19 ng/mg creatinine), and were even higher in sPE compared with mild preeclampsia (21.20 vs. 2.77 ng/mg creatinine, respectively; P <
Filiaciones:
Márquez-Acosta J.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Cárdenas-Mondragón G.M.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Chinolla-Arellano Z.L.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Rivera-Leaños R.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Bermejo-Huerta S.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Romero-Arauz J.F.:
Hypertensive Diseases of Pregnancy Clinic, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Alvarez-Jiménez G.:
Hypertensive Diseases of Pregnancy Clinic, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Ramos-León J.C.:
Hypertensive Diseases of Pregnancy Clinic, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Ulloa-Aguirre A.:
Research Unit in Reproductive Medicine, Hospital de Ginecología Y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México 03500 D.F., Mexico
Research Unit in Reproductive Medicine, Don Luis no. 111, Col. Nativitas, México 03500, D.F., Mexico
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