Internal desynchronization in a model of night-work by forced activity in rats
Por:
Salgado-Delgado, R, Angeles-Castellanos, M, Buijs, MR, Escobar, C
Publicada:
26 jun 2008
Categoría:
Neuroscience (miscellaneous)
Resumen:
Individuals engaged in shift- or night-work show disturbed diurnal rhythms, out of phase with temporal signals associated to the light/dark (LD) cycle, resulting in internal desynchronization. The mechanisms underlying internal desynchrony have been mainly investigated in experimental animals with protocols that induce phase shifts of the LD cycle and thus modify the activity of the suprachiasmatic nucleus (SCN). In this study we developed an animal model of night-work in which the light-day cycle remained stable and rats were required to be active in a rotating wheel for 8 h daily during their sleeping phase (W-SP). This group was compared with rats that were working in the wheel during their activity phase (W-AP) and with undisturbed rats (C). We provide evidence that forced activity during the sleeping phase (W-SP group) alters not only activity, but also the temporal pattern of food intake. In consequence W-SP rats showed a loss of glucose rhythmicity and a reversed rhythm of triac
Filiaciones:
Salgado-Delgado, R:
Univ Nacl Autonoma Mexico, Dept Anat, Fac Med, Mexico City 04510, DF, Mexico
Angeles-Castellanos, M:
Univ Nacl Autonoma Mexico, Dept Anat, Fac Med, Mexico City 04510, DF, Mexico
Buijs, MR:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Escobar, C:
Univ Nacl Autonoma Mexico, Dept Anat, Fac Med, Mexico City 04510, DF, Mexico
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