Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis
Por:
Aquino-Galvez A., Camarena Á., Montano, M, Juarez A., Zamora A.C., González-Avila G., Checa M., Sandoval-López G., Vargas-Alarcon G., Granados J., Pardo A., Zuniga, J, Selman M.
Publicada:
1 abr 2008
Resumen:
Hypersensitivity pneumonitis (HP) is a lung inflammatory disease caused by the inhalation of a variety of antigens. Previous studies support the role of the major histocompatibility complex (MHC) class II genes in the susceptibility to develop HP. However, the putative role of other MHC loci has not been elucidated. Transporters associated with antigen processing (TAP) genes are located within the MHC class II region and play an important role transporting peptides across the endoplasmic reticulum membrane for MHC class I molecules assembly. The distribution of single nucleotide polymorphisms (SNPs) in TAP1 genes was analyzed in 73 hypersensitivity pneumonitis (HP) patients and 58 normal subjects. We found a significant association of the allele Gly-637 (GGC) (p = 0.00004, OR = 27.30, CI = 3.87-548.04) and the genotypes Asp-637/Gly-637 (p = 0.01, OR = 16.0, CI = 2.19-631.21), Pro-661/Pro-661 (p = 0.006, OR = 11.30, CI = 2.28-75.77) with HP. A significant decrease in the frequency of the allele Pro-661 (CCA) (p = 0.008, OR = 0.06, CI = 0-0.45), the genotype Asp-637/Asp-637 (p = 0.01, OR = 0.17, 95% CI = 0.05-0.58) and the haplotype [Val-333 (GTC), Val-458 (GTG), Gly-637 (GGC), Pro-661 (CCA)] was detected in HP patients compared with controls (p = 0.002, OR = 0.07, CI = 0.0-0.57). These findings suggest that TAP1 gene polymorphisms are related to HP risk, and highlight the importance of the MHC in the development of this disease. © 2008 Elsevier Inc. All rights reserved.
Filiaciones:
Aquino-Galvez A.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Camarena Á.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Juarez A.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Zamora A.C.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
González-Avila G.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Checa M.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Sandoval-López G.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
Vargas-Alarcon G.:
Instituto Nacional de Cardiología Ignacio Chávez., Juan Badiano 1, Col Sección XVI, Mexico City, Mexico
Granados J.:
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Col. Seccion XVI, 14050, Mexico City, Mexico
Pardo A.:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico
Selman M.:
Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico
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