Development and validation of liquid chromatography method for quantification of the active markers of Hintonia standleyana and Hintonia latiflora crude drugs
Por:
Mata, R, Acevedo, L, Mendez-Bautista, DI, Guerrero-Analco, JA, Rivero, BE, Rodriguez, JM
Publicada:
1 ene 2008
Resumen:
The infusions prepared from the stem-bark of Hintonia latiflora (Sesse et Mocino ex DC) Bullock or Hintonia standleyana Bullock (Rubiaceae) are indistinctly used in Mexican traditional medicine for the treatment of non-insulin-dependent diabetes mellitus and malaria fevers. Suitable high-performance liquid chromatography (HPLC)-UV methods for quantitative determination of 5-O-[beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranosyl]-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin (1) and 5-0-[beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranosyl]-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin (2) in the infusions of H. standleyana and H. latiflora, respectively, were established. Coumarins I and 2 are the major antihyperglycemic compounds found in the infusions prepared from stem-bark of H. standleyana and H. latiflora, respectively, and are proposed as the active markers. The methods were found to be reliable, reproducible, and accurate.
Filiaciones:
Mata, R:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
Acevedo, L:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
Mendez-Bautista, DI:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
Guerrero-Analco, JA:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
Rivero, BE:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
Rodriguez, JM:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia, Mexico City 04510, DF, Mexico
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