Etiopathogenesis of Burkitt's lymphoma: a lesson from a BL-like in CD1 mouse immune to Plasmodium yoelii yoelii
Por:
Malagon, F, Gonzalez-Angulo, J, Carrasco, E, Robert, L
Publicada:
1 ene 2011
Resumen:
Introduction: There is a jaw cancer that develops in children five to eight years old in holoendemic malaria regions of Africa, associated to malaria and Epstein Barr virus infections (EBV). This malignancy is known as endemic Burkitt's lymphoma, and histopatologically is characterized by a starry sky appearance. To date, no histopathologic expression of Burkitt's lymphoma has been reported in non-genetically manipulated experimental animals. The purpose of the study is to describe the case of a mouse immune to Plasmodium yoelii yoelii (Pyy) that developed a Burkitt's lymphoma-like neoplasm after repeated malaria infections. Results: Immune mouse 10 (IM-10) developed neoplasms at eight months of age, after receiving three Pyy inoculations. At autopsy eight subcutaneous tumors were found of which the right iliac fosse tumor perforated the abdominal wall and invaded the colon. The histopathologic study showed that all neoplasms were malignant lymphomas of large non-cleaved cells also com
Filiaciones:
Malagon, F:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Lab Malariol, Fac Med, Mexico City 04510, DF, Mexico
Gonzalez-Angulo, J:
Univ Nacl Autonoma Mexico, Fac Estudios Profes, Iztacala, Edo De Mexico, Mexico
Carrasco, E:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Lab Malariol, Fac Med, Mexico City 04510, DF, Mexico
Robert, L:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Lab Malariol, Fac Med, Mexico City 04510, DF, Mexico
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