Crystal structure of tricolorin A: Molecular rationale for the biological properties of resin glycosides found in some Mexican herbal remedies


Por: Rencurosi A., Mitchell E.P., Cioci G., Pérez S., Pereda-Miranda R., Imberty A.

Publicada: 1 ene 2004
Resumen:
A water channel was observed in the first crystallographically determined structure of a natural resin glycoside (see figure). Tricolorin A displays amphipathic features, which have been correlated with its significant mammalian and plant toxicity. The architecture of tricolorin A in the solid state suggests that the cytotoxicity of this class of compounds may be the result of their pore-forming ability.
ISSN: 14337851





ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Editorial
Wiley-VCH Verlag, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY, Alemania
Tipo de documento: Article
Volumen: 43 Número: 44
Páginas: 5918-5922
WOS Id: 000225337000009
ID de PubMed: 15382201