Crystal structure of tricolorin A: Molecular rationale for the biological properties of resin glycosides found in some Mexican herbal remedies
Por:
Rencurosi A., Mitchell E.P., Cioci G., Pérez S., Pereda-Miranda R., Imberty A.
Publicada:
1 ene 2004
Resumen:
A water channel was observed in the first crystallographically determined structure of a natural resin glycoside (see figure). Tricolorin A displays amphipathic features, which have been correlated with its significant mammalian and plant toxicity. The architecture of tricolorin A in the solid state suggests that the cytotoxicity of this class of compounds may be the result of their pore-forming ability.
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