Retinoblastoma en un adolescente. Hallazgos clinicopatológicos poco frecuentes
Por:
Hernández-Ayuso I., Ríos y Valles-Valles D., Lome-Maldonado C., Gómez-Leal A., Rodríguez-Martínez H.A., Rodríguez-Reyes A.A.
Publicada:
1 ene 2016
Categoría:
Ophthalmology
Resumen:
Case report A 17-year- old male with 2 years history of an intraocular mass and progressive visual loss of the left eye. Spontaneous sclera rupture occurred during enucleation. Microscopic evaluation with H-E, PAS and immunohistochemistry (NSE, GAFP, SYN, CD99) revealed a small blue round cell malignant neoplasm with extensive necrosis and apoptosis. The optic nerve, ciliary body, choroid, anterior chamber, and sclera were infiltrated. SYN was positive and CD99 was negative in neoplastic cells, consistent with a poorly differentiated retinoblastoma. Discussion Retinoblastoma is the most frequent primary intraocular malignant tumour in childhood, but occasionally older patients can be affected. Immunohistochemistry is mandatory in poorly differentiated retinoblastomas. © 2015 Sociedad Española de Oftalmología.