An increase in IL-1ß concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation
Por:
Sequeira K., Espejel-Núñez A., Vega-Hernández E., Molina-Hernández A., Grether-González P.
Publicada:
1 ene 2015
Resumen:
Purpose: This study aimed to evaluate interleukin (IL)-1? concentrations in maternal serum and in embryo-cultured conditioned media and to correlate these findings with success of implantation. Methods: A total of 70 infertile women who underwent in vitro fertilization treatment were studied. IL-1? concentrations were quantified in maternal serum and in embryo culture-conditioned media on days 1 and 3. The findings were compared between those who achieved pregnancy and those who did not. Results: No significant differences were found in IL-1? serum concentrations between the groups. IL-1? was not detected in day 1 culture-conditioned medium. On day 3, IL-1? was quantified in 27 patients, and IL-1? concentrations were significantly higher in women who achieved pregnancy than in those who did not (p < 0.001). Conclusions: High IL-1? concentrations in day 3 culture-conditioned medium in patients who achieve pregnancy after in vitro fertilization treatment indicate a possible role of embryonic IL-1? in the implantation process. © 2015, The Author(s).
|