Prevalencia de enfermedad renal en niños aparentemente sanos con antecedente familiar de terapia de reemplazo renal
Por:
Medeiros M., Andrade Veneros G.D., Toussaint Martínez de Castro G., Ortiz Vásquez L., Hernández Sánchez A.M., Olvera N., Obrador Vera G.T., Velásquez Jones L.
Publicada:
1 jul 2015
Categoría:
Pediatrics, Perinatology and Child Health
Resumen:
Background: Having a first- or second-degree relative with chronic kidney disease (CKD) has been reported as a risk factor for CKD development. The aim of the study was to determine the prevalence of CKD in children with a first- or second-degree relative undergoing renal replacement therapy (hemodialysis or renal transplant). Methods: A screening study was performed in asymptomatic children with a family history of CKD in a first- or second-degree relative undergoing renal replacement therapy. Informed consent was obtained in all cases. A clinical examination was performed. Blood and urine samples were obtained for serum creatinine, serum electrolytes, urinalysis, and microalbumin/creatinine ratio. Results: There were 45 subjects included with a median age of 9.6 years; 24 (53%) were male. Urinary abnormality/CKD was observed in 11 subjects (24.4%). The most common urinary abnormalities were hematuria (6/11) and microalbuminuria (4/11). Stage 2 CKD was found in seven subjects and four subjects with stage 1 CKD. Conclusions: The study of families of patients undergoing renal replacement therapy is useful to identify children in early stages of kidney disease. © 2015 Hospital Infantil de México Federico Gómez.
Filiaciones:
Medeiros M.:
Laboratorio de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, México D.F., Mexico
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Andrade Veneros G.D.:
Departamento de Nefrología, Hospital Infantil de México Federico Gómez, México D.F., Mexico
Toussaint Martínez de Castro G.:
Laboratorio de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, México D.F., Mexico
Ortiz Vásquez L.:
Laboratorio de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, México D.F., Mexico
Hernández Sánchez A.M.:
Laboratorio de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, México D.F., Mexico
Olvera N.:
Fundación Mexicana del Riñón A.C., México D.F., Mexico
Obrador Vera G.T.:
Escuela de Medicina, Universidad Panamericana, México D.F., Mexico
Velásquez Jones L.:
Departamento de Nefrología, Hospital Infantil de México Federico Gómez, México D.F., Mexico
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