Filtration influence on dissolution profile of solid pharmaceutical forms [Influencia de la filtración en el perfil de disolución de formas farmacéuticas sólidas]
Por:
Fuentes N I., Rodríguez A S.M., Castro T N., Sánchez P C.F., Zúñiga B M.M.
Publicada:
1 ene 2002
Resumen:
The dissolution profiles have a considerable importance in the pharmaceutical control. It has been used properly as a control device to ensure processes and batches consistencies for a particular formulation, also have been a valuable tool in designing solid dosage forms. The results obtained from dissolution profiles may serve as a guide to the formulator in selecting a dosage form design. The dissolution data may involve factors related to drugs dissolution rate, drug particle size and disintegration rate of the dosage forms and factors related with methodology of the test in which could exist several factors that could be influenced the results obtained. One of these factors is the filtration process, in this methodology different sizes of the pore are utilized commonly: Millipore membrane (MM, 0.45 ?m), Teflon filter (TF < 10 ?m) and Whatman paper (WP, 2.5 ?m). The object of this study was to determinate the influence of filtration process over the dissolution test on products of alfa metil- dopa, glibenclamide, ibuprofen, indomethacin, propanolol, prednisone, clorthalidone and nitrofurantoin on three different filters. The obtained results showed that exist significantly differences of lot on products such as prednisone, nitrofurantoin and glibenclamide. The influence on filtration process were presented in different lots, mainly drugs that shown pharmaceutical problems of water solubility.