In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells
Por:
Sánchez I., Calderón J., Ruiz B., Tellez J., Calzada L., Taboada J.
Publicada:
1 ene 2001
Resumen:
The cytotoxic effect of five flavonoids isolated from the aerial parts of the Asteraceae family of plants were studied in vitro using LLC-MK2 and C6 glial cells. Agehoustin A was shown to be cytotoxic for both cells (71% or 67% cell death). Agehoustin B and artemetin, which lack a methoxy group at C-8 (RI), were not cytotoxic for the cells (19% and 16% cell death). The three flavonoids showed considerable suppressive effects on LLC-MK2 and C6 cell growth. Lucidin-dimethylether and gnaphaliin were also not cytotoxic for cells but they had no suppressive effect on cell growth. The results show a structure-cytostatic activity relationship. We suggest that the methoxy group on C-8 and on the B ring are responsible for death cell. Copyright © 2001 John Wiley & Sons, Ltd.
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