Hypoglycemic activity of root water decoction, sesquiterpenoids, and one polysaccharide fraction from Psacalium decompositum in mice


Por: Alarcon-Aguilar F.J., Jimenez-Estrada M., Reyes-Chilpa R., Gonzalez-Paredes B., Contreras-Weber C.C., Roman-Ramos R.

Publicada: 1 ene 2000
Resumen:
The hypoglycemic activity of Psacalium decompositum (Asteraceae) was investigated in fasting healthy mice and alloxan-diabetic mice. The freeze- dried water decoction significantly reduced the blood glucose in normal mice (from 50.9 ± 4.7 to 32.5 ± 3.1 mg/dl) and in mild diabetic mice (from 208.5 ± 13.0 to 52.3 ± 7.0 mg/dl), 240 min after intraperitoneal administration (P < 0.005). This preparation also diminished fasting glycemia in severe diabetic mice, but the effects were minor (from 394.4 ± 9.4 to 289.3 ± 39.5 mg/dl). The main sesquiterpenoid constituents from P. decompositum roots, cacalol, cacalone and maturin, as well as the transformation product cacalol acetate, did not show a hypoglycemic effect on healthy mice. Nevertheless, two polysaccharide fractions (F1 and F3) obtained from the freeze-dried water extract significantly reduced the fasting glycemia in healthy mice. The best results were obtained with the F1 fraction. (C) 2000 Elsevier Science Ireland Ltd.
ISSN: 03788741
Editorial
ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND, Irlanda
Tipo de documento: Article
Volumen: 69 Número: 3
Páginas: 207-215
WOS Id: 000085512200002
ID de PubMed: 10722202